Phenolics with Leishmanicidal and Immunomodulatory Properties
نویسندگان
چکیده
منابع مشابه
Novel immunomodulatory function of 1,3,4-thiadiazole derivatives with leishmanicidal activity.
OBJECTIVES Previously, some nitroheteroaryl-1,3,4-thiadiazole derivatives were identified to have potent activity against Leishmania sp. The present aim was to complete the in vitro analysis, thereby investigating the in vivo efficiency of the analogues 15a, 21a and 21b against infected BALB/c mice. METHODS Following parasite inoculation and intraperitoneal drug administration (5 and 20 mg/kg...
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The plant phenolic compounds such as flavonoids, tannins and phenolic acids appeared to be strong antiradical and antioxidant compounds. The number of hydroxy groups and the presence of a 2,3-double bond and orthodiphenolic structure enhance antiradical and antioxidative activity of flavonoids. The glycosylation, blocking the 3-OH group in C-ring, lack of a hydroxy group or the presence of only...
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ژورنال
عنوان ژورنال: Revista Facultad de Ciencias Básicas
سال: 2014
ISSN: 1900-4699,2500-5316
DOI: 10.18359/rfcb.342